Semaglutide was approved by the FDA for type 2 diabetes to lower blood sugar and maintain acceptable blood sugar levels. However, the more semaglutide was used and studied clinicians discovered that semaglutide had other positive benefits such as improved cardiovascular risk, decreased inflammation, decreased appetite, and weight loss.
In 2019 Semaglutide was FDA approved for weight loss use in patients with a BMI of 30 or greater, or a BMI of 27 and greater with at least one comorbidity. Comorbidities include cardiovascular issues.
Semaglutide is a glucagon-like peptide-1 receptor agonist. It mimics the action of the incretin GL-1 by improving the production of insulin, a hormone that lowers blood sugar levels. In addition, semaglutide works by controlling your appetite, and the peptide semaglutide reduces the prompts in the brain that control food intake and appetite. In addition to using Semaglutide, an exercise program and reduced caloric intake will help aid in weight loss goals and long-term management.
Semaglutide is a subcutaneous injection given once a week at home.
Nausea, vomiting, & diarrhea are the most common side effects, but they usually subside after a few weeks of using the medication. Rare side effects include kidney damage, gall bladder disease, and pancreatitis. These demand immediate medical attention.
Dosages are based on health conditions and your response to the treatments. Start at a low dose and gradually increase your dose. Follow your provider’s instructions. Semaglutide for weight loss is typically used for 3- 6 months.